We help founders build

a healthier & more sustainable future.

Wireframe Ventures

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We help founders who

harness biology to

engineer better products

.

Investing in technology for people & planet

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We help founders who

create scalable solutions to

climate change

.

Investing in technology for people & planet

We help founders who

deploy AI & automation to

empower us

.

Investing in technology for people & planet

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We help founders who

deliver healthcare that's

personal & proactive

.

Investing in technology for people & planet

Because they are cool
and helpful

We help founders who

transport us safely, with

zero carbon footprint

.

Investing in technology for people & planet

Because they are cool
and helpful
Our Purpose.

We invest capital, time & belief to accelerate your success.

Every startup journey is unique - there's no single playbook that works for everyone, especially in the early days. We try to meet you where you are and help you get where you dream of going. We listen with empathy, we tell you the truth and we'll dive in to contribute hands-on support whenever you need it. You should expect nothing less from any investor.
We invest in driven founders who can build pioneering companies that improve our world.
We partner closely with our founders from the beginning, and we're on call when they need us most.

Harsh was the first VC we met who immediately understood our potential, and he's been a trusted mentor to me since our seed round. His empathy & experience building companies in our space make him an ideal investor for any 1st-time founder."

Trevor Martin

Founder & CEO, Mammoth Biosciences
"

Wireframe led our seed round and they’ve been invaluable to me as a solo founder. I’ve been able to rely on Paul as a true partner. We have an open, trusted relationship that goes well beyond what most founders might expect from their investors."

Arch Rao

Founder & CEO, SPAN
"

Paul and Harsh have been great partners ever since Wireframe led our seed round at Full Harvest. They're engaged, always happy to help and bring real startup expertise that makes them stand out above the rest."

Christine Moseley

Founder & CEO, Full Harvest
"

Before we ever raised capital, Harsh introduced us to our lead scientific advisor & spent hours with us on a whiteboard helping to hone our thinking. The Wireframe team were great partners at GeneWEAVE and we're excited to work with them again."

Diego Rey

Co-founder & CSO, Endpoint Health
"

Harsh is a great partner, in both good & tough times. He’s always available to help and pushes us to a high standard. And we'll forever appreciate his clarity & conviction to go all-in on Airflow, a decision that changed the course of our company."

Ry Walker

Founder, Astronomer
"

Wireframe's value to MycoWorks far exceeds the size of their check. This is the second time I've worked with Paul. He's always available, responsive and thoughtful. I trust his input and contribution as a true partner in building my business."

Matt Scullin

CEO, Mycoworks
"

Harsh brings a lifetime of wisdom coupled with uncanny insight, empathy, and authentic conviction to his investments. He is single-handedly the "accelerator" you wished existed. He'll be the first person I call when I start my next company."

Viswa Colluru

Founder & CEO, Enveda Biosciences
"

Paul led our seed round and has been with me for the 7+ years since, through all of the highs and lows. There's no better partner I can imagine. Many investors say they are founder first - Paul's the real deal."

Andy Ruben

Founder & CEO, Trove
"

Wireframe was among the first funds to believe in us, and Paul and Harsh have been the most reliable, empathetic partners ever since. Whether supporting & advising us day-to-day or navigating a global crisis, I knew I could always lean on them."

Rema Matevosyan

Co-founder & CEO, Near Space Labs
"

I've worked with Harsh over 13 years as an investor in 2 of my companies. I’ve relied on his honesty and perspective on company-building time & time again. Having met hundreds of investors, he is easily in my top 5 of all time."

Tim Enwall

CEO, Misty Robotics
"
Our Portfolio.

Our founders are on a mission to build a better future.

Product.
Purpose.
People.
Product.
Purpose.
People.
Product.
Purpose.
People.
People.
People.
Purpose.
Purpose.
Product.
Product.
People.
Product.
Purpose.
People.
Product.
Purpose.
People.
Product.
Purpose.
Product.
Product.
People.
People.
Purpose.
Purpose.
Purpose.
People.
Product.
Purpose.
People.
Product.
Purpose.
People.
Product.
Purpose.
Purpose.
Product.
Product.
People.
People.
Bioscience

Improving human health with new diagnostics & therapeutics built with CRISPR

Mammoth Biosciences

Seed
January 2018
Discovering & commercializing novel CRISPR systems that enable new possibilities for expanding biology
Retail

Powering a new circular economy for the world's best retail brands

Trove

Seed
May 2013
Driven by a belief that sustainability is the only way forward for retail, helping brands succeed & the world thrive
Energy

The new interface for home energy

SPAN.io

Seed
December 2018
Making home energy connected & intuitive with a smart electrical panel that makes it easier to adopt clean energy
Enterprise

Empowering organizations to solve their most challenging problems

Palantir

Series A
October 2005
Software empowering organizations with the insights they need to solve complex, mission-critical problems (NYSE: PLTR)
Agriculture

Solving food waste at the farm level

Full Harvest

Seed
October 2016
Optimizing the agricultural supply chain with a business marketplace for imperfect & surplus produce
Retail

A new class of material, sustainably crafted from nature

Mycoworks

Series A
May 2019
Bioengineering a sustainable, high-performance & animal-free alternative to leather using fine mycelium
Bioscience

Applying AI to engineer next-generation cancer therapies

Reverie Labs

Seed
March 2018
Solutions for the most difficult, multi-objective medicinal chemistry problems to fill pressing medical needs
Financial Services

Believing in the power of values-based investing

OpenInvest

Seed
May 2017
Making it simple, and profitable, to align your investments with your values
Bioscience

Simplifying renewable energy procurement for any corporation

LevelTen Energy

Series A
September 2017
The industry's leading platform for corporate energy buyers to find the right renewable energy solutions
Our Team.

Meet our founders.

Harsh Patel

  • Co-Founder
  • Managing Director

Paul Straub

  • Co-Founder
  • Managing Director

Committed to your success.

We started Wireframe to serve founders solving some of the world's most important challenges. Over the years as investors & operators, we've built networks and domain expertise across themes we care deeply about. And we've been fortunate to work closely with founders from inception to success. As 1st check investors, we are completely aligned with you from the start.

Our Community.

Climb together.

We're building a community where founders can share hard-earned lessons with their peers and pay it forward to the next generation when they succeed.